DïGEN LABS
PHARMACOGENETIC (PGx) TESTING
Pharmacogenetic testing is recommended by the U.S. FDA
as well as the Department of Health and Human Services.
Pharmacogenetic testing looks at how your unique genetic makeup can affect your response to medications and helps your clinician find the medications that may be right for you. Through the analysis of certain genes that metabolize certain medicines, health care professionals can now have key information to determine the most appropriate dose to the most appropriate medicines for each individual patient.
Critical values are reported to caregivers as soon as they are available. These elements and our devotion to customer service set us apart from our competitors.
The goal of DïGEN LABS is to provide Pharmacogenetic testing to:
- Optimize a clinician’s drug choice for a patient
- Improve dosing for more effective therapy
- Avoid serious Adverse Drug Reactions (ADR’s)
- Decrease overall medical costs
DïGEN LABS
UNDERSTANDING PHARMACOGENETICS
Blood Wellness panels are groups of tests that determine a patient’s general health.
The Department of Health and Human services provides a list of FDA-approved drugs with
Pharmacogenetic information in their labeling. Some biomarker information recommends
specific actions to be taken by your physician. Pharmacogenetic testing information
can provide your physician critical guidance in this area. This is done by analyzing your genetic metabolic
rates against pharmacogenetic information from various drugs.
Drug metabolism rates vary among patients. Some patients metabolize a drug so rapidly that therapeutically
effective blood and tissue concentrations are not reached; in others, metabolism may be so slow that usual
doses have toxic effects. The term metabolizer is used to indicate how a patient may process a certain type
of drug or enzyme. When coupled with genetic analysis, an accurate measure of how a patient will respond to
certain drugs can be established.
Knowing a patient’s genetic profile can help a prescriber adjust patient drug therapy to
improve therapeutic outcomes and reduce the risk of adverse drug events (ADE).
What will a pharmacogenetic test do for you?
Pharmacogenetic testing allows the physician to understand how a patient's genetic make-up
influences the effectiveness of a medication within the patiuent's body, as well as what side effects will
occur. Rather than having to take the standard trial-and-error approach to the patients’
prescription drug therapy, physicians can now prescribe the right medicine, for the
right patient at the right time. Not only will this take the guesswork out of finding
the right drug, it will reduce costs, speed recovery time and increase safety as the
likelihood of adverse reactions is eliminated.
OUR
3 STEP PHARMACOGENETICS ANALYSIS PROCESS
Our Pharmacogenetic test report categorizes a patient into one of four metabolizer categories for each
genetic pathway and interprets that data in the context of the following specialties areas:
- Cardiovascular Health
- Psychiatry
- Neurology
- Woman’s Health
- Primary Care
- Pain Management
At DïGEN LABS, we have a three step process that produces an exceptional analysis that enables healthcare professionals to make a better, more informed therapeutic decision. for their patients. Through our process we Analyze genes, Assign them a metabolic rate category, and then provie a detailed Report to help understand how certain drugs will affect the patient.
ANALYZE
DïGEN LABS will compare certain specific genetic markers to detrmine how the patient will
will react to specific medications. Below is a list of genes that DïGEN LABS analyzes and the
medications that the gene is tested against.
CYP1A2
(Gene Name)
Medication Comparision
All therapeutic medication classes
CYP2C9
(Gene Name)
Medication Comparision
All therapeutic medication classes
CYP2C19
(Gene Name)
Medication Comparision
All therapeutic medication classes
CYP2D6
(Gene Name)
Medication Comparision
All therapeutic medication classes
CYP3A4
(Gene Name)
Medication Comparision
All therapeutic medication classes
CYP3A5
(Gene Name)
Medication Comparision
All therapeutic medication classes
SLC6A4
(Gene Name)
Medication Comparision
Antidepressants
HTR2A
(Gene Name)
Medication Comparision
SSRIs, Antipsychotics
COMT
(Gene Name)
Medication Comparision
Antidepressant, Pain, ADHA
DRD2
(Gene Name)
Medication Comparision
Antipsychotics
MTHFR
(Gene Name)
Medication Comparision
Adjunctive treatment for depression, Psychosis
VKORC1
(Gene Name)
Medication Comparision
Anticoagulation (warfarin)
OPRM1
(Gene Name)
Medication Comparision
Opioids
SLCO1B1
(Gene Name)
Medication Comparision
Statins (simvastatin)
ABCB1
(Gene Name)
Medication Comparision
Pain
ADRA2A
(Gene Name)
Medication Comparision
Antidepressants, Antipsychotics, ADHD
F2 (Factor 2)
(Gene Name)
Medication Comparision
Anticoagulants
FV (Factor V)
(Gene Name)
Medication Comparision
Anticoagulants
HTR2C
(Gene Name)
Medication Comparision
Antipsychotics
GRIK4
(Gene Name)
Medication Comparision
AGlutamate functions of central nervous systems
NAT2
(Gene Name)
Medication Comparision
Arylamine, Hydrazine Drugs, Carcinogens
Apoε
(Gene Name)
Medication Comparision
Hyperlipidemia
ASSIGN
DïGEN LABS will assign a metabiolic category to each of the patients genetic markers
used for analysis. These metabolizers will identify how effective a particular drug will
work given the patients genetic profile. Pharmacogenetic testing is only used to find out a
person's response to a specific medicine.
Our four metabolic categories are:
1 ULTRA-RAPID METABOLIZERS
- Increased risk of treatment failure from non-prodrugs* due to increased metabolism.
- Increased risk of toxicity from prodrugs* due to excessive formation of active metabolites.
2 NORMAL METABOLIZERS
- Normal drug metabolism should be expected.
3 INTERMEDIATE METABOLIZERS
- Often a reduced dose of non-prodrugs* is suggested with close monitoring for ADE’s.
- Administration of inhibitors could result in poor metabolizer ability; administration of inducers could improve metabolism.
4 POOR METABOLIZERS
- Increased risk of toxicity from non-prodrugs* due to lack of metabolism.
- Unlikely to benefit from prodrugs* due to reduced formation of active metabolites.
REPORT
The results of a DïGEN LABS Pharmacogenetic test allow a healthcare professional to make a more informed
therapeutic decision. They may change the current medication or class of medication prescribed,
adjust dosing based on the metabolic status or find more appropriate alternative medications
based on the test results.
Pharmacogenetic testing allows your physician to understand how your genetic make-up determines
how well a medicine works in your body, as well as what side effects will occur. Rather than
having to take the standard trial-and-error approach to their patients’ prescription drug
therapy, physicians can now prescribe the right medicine, for the right patient at the
right time. Not only will this take the guesswork out of finding the right drug, it will
reduce costs, speed recovery time and increase safety as the likelihood of adverse reactions
is eliminated.
What We Do
LEARN MORE ABOUT
DïGEN LABS LABORATORY SERVICES
DïGEN LABS’s state of the art COLA accredited laboratory provides physicians and patients with a full suite of high quality laboratory tests and services. DïGEN LABS’s laboratory provides fast and accurate results and offers screening results within 24 hours and full confirmation within 48 hours. Direct consultations with our scientists are available.
DïGEN LABS’s laboratory services include routine Blood Wellness testing, such as basic blood counts and cholesterol tests, therapeutic Medication Monitoring (Toxicology), along with highly complex methods that diagnose genetic variations that effect individual responses to medicines (PGx).
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CONTACT DïGEN LABS
Contact DïGEN LABS today to see how we can help meet your laboratory services.
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Contact DïGEN LABS and see why we are the accurate, dependable, on-time clinical laboratory of choice for physicians and patients all across the United States.
The Office
DïGEN LABS
2211 Century Center Boulevard, Suite 110
Irving, TX 75062
Phone: (469) 565-3300
Fax: (469) 565-3476
email: [email protected]
DïGEN LABS Houston Sales Office
11111 Katy Freeway, 910
Houston, TX 77079
Phone: (855) 277-1276
Fax: (888) 636-7540
Email: [email protected]
About DïGEN LABS
DïGEN LABS is a high-complexity CLIA and CAP accredited laboratory specializing in biochemistry, cytogenetics, microbiology, molecular genetics, pharmacology, and toxicology.